ea0037oc7.2 | Neuroendocrinology and pituitary-basic | ECE2015
Sanchez-Rebordelo Estrella
, Imbernon Monica
, Gallego Rosalia
, Gandara Marina
, Lear Pamela
, Lopez Miguel
, Dieguez Carlos
, Nogueiras Ruben
Introduction: Krüpel-like factor 4 (KLF4) is a zinc-finger-type transcription factor expressed in a range of tissues that plays multiple functions. KLF4 is expressed in neural stem cells and is critical to neuronal differentiation. Recent evidence suggests that KLF4 also plays an important role in the central regulation of energy balance. In vitro studies show that KLF4 is a transcriptional regulator of agoutiĀrelated protein (AgRP), essential to the hyperph...